cftr

Single-cell CFTR image-analysis pipeline for the mCherry-YFPCFTR quenching assay. The pipeline includes a custom-made Cellpose model for image segmentation, and per-cell quantification of CFTR membrane proximity and function.

Interactive Academic Research Capstone on Vertex CFTR Modulators for Cystic Fibrosis | Live on GitHub Pages

Beginner-friendly, provenance-honest Jupyter notebooks for interpreting CFTR variants: population frequency, missense pathogenicity predictors, and the ClinVar and CFTR2 truth sets — including why a predictor can't be fairly graded on labels it trained on. Four of eight per-CFTR extracts ship ready to run. More tools in progress.

QSAR modeling of CFTR potentiators using RDKit + ML