diff --git a/docs/supporting-a-new-node-version.md b/docs/supporting-a-new-node-version.md
index bd4068d03eb5..d38b3e245f93 100644
--- a/docs/supporting-a-new-node-version.md
+++ b/docs/supporting-a-new-node-version.md
@@ -93,15 +93,10 @@ Reference: [#20710](https://github.com/getsentry/sentry-javascript/pull/20710)
    - [ ] `@sentry-internal/node-native-stacktrace` in `packages/node-native/package.json`
    - [ ] Run `yarn install` to update `yarn.lock`
 
-3. Register the new ABI in the profiling pruner. In
-   `packages/profiling-node/scripts/prune-profiler-binaries.js`:
-   - [ ] Add the Node major to ABI mapping to the `NODE_TO_ABI` object (e.g. `26: '147'`).
-   - [ ] Add the corresponding `else if (NODE.startsWith('26'))` branch.
-
-4. Allow the new major in the profiling integration, in `packages/profiling-node/src/integration.ts`:
+3. Allow the new major in the profiling integration, in `packages/profiling-node/src/integration.ts`:
    - [ ] Add the version number to the `if (![16, 18, 20, 22, 24, 26].includes(NODE_MAJOR))` guard
    - [ ] Add the version to the supported-versions list in the `console.warn` message below the guard (the string that reads `...prebuilt support for the following LTS versions of Node.js: 16, 18, 20, 22, 24.`)
 
-5. Handle deprecation warnings. Each new Node version tends to deprecate APIs the SDK (or its dependencies) still use, which can break tests that assert on clean stderr or console output.
+4. Handle deprecation warnings. Each new Node version tends to deprecate APIs the SDK (or its dependencies) still use, which can break tests that assert on clean stderr or console output.
 
-6. Fix version-specific test failures, some integrations or test dependencies may not yet work on the new version.
+5. Fix version-specific test failures, some integrations or test dependencies may not yet work on the new version.
diff --git a/packages/profiling-node/README.md b/packages/profiling-node/README.md
index 078911c27a3f..be1e4dbfe658 100644
--- a/packages/profiling-node/README.md
+++ b/packages/profiling-node/README.md
@@ -234,46 +234,8 @@ require('esbuild').build({
 
 Once you run `node esbuild.serverless.js` esbuild wil bundle and output the files to ./dist folder, but note that all of
 the binaries will be copied. This is wasteful as you will likely only need one of these libraries to be available during
-runtime.
-
-> **Deprecation notice:** This script will be removed in the next major version. If you depend on it, please comment on
-> [this issue](https://github.com/getsentry/sentry-javascript/issues/20567).
-
-To prune the other libraries, profiling-node ships with a small utility script that helps you prune unused binaries:
-
-```bash
-npx --package=@sentry/profiling-node sentry-prune-profiler-binaries
-```
-
-Use `--help` to see a list of available options or `--dry-run` if you want it to log the binaries that would have been
-deleted.
-
-Example of only preserving a binary to run node16 on linux x64 musl.
-
-```bash
-npx --package=@sentry/profiling-node sentry-prune-profiler-binaries --target_dir_path=./dist --target_platform=linux --target_node=16 --target_stdlib=musl --target_arch=x64
-```
-
-Which will output something like
-
-```
-Sentry: pruned ./dist/sentry_cpu_profiler-darwin-x64-108-IFGH3SUR.node (90.41 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-darwin-x64-93-Q7KBVHSP.node (74.16 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-arm64-glibc-108-NXSISRTB.node (52.17 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-arm64-glibc-83-OEQT5HUK.node (52.08 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-arm64-glibc-93-IIXXW2PN.node (52.06 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-arm64-musl-108-DSILNYHA.node (48.46 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-arm64-musl-83-4CNOBNC3.node (48.37 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-arm64-musl-93-JA5PKNWQ.node (48.38 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-x64-glibc-108-NXSISRTB.node (52.17 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-x64-glibc-83-OEQT5HUK.node (52.08 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-x64-glibc-93-IIXXW2PN.node (52.06 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-x64-musl-108-CX7SL27U.node (51.50 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-linux-x64-musl-83-YD7ZQK2E.node (51.53 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-win32-x64-108-P7V3URQV.node (181.50 KiB)
-Sentry: pruned ./dist/sentry_cpu_profiler-win32-x64-93-3PKQDSGE.node (181.50 KiB)
-✅ Sentry: pruned 15 binaries, saved 1.06 MiB in total.
-```
+runtime. Since the binaries follow the `sentry_cpu_profiler-<platform>-<arch>-<stdlib>-<abi>.node` naming scheme, you can
+delete the ones that do not match your target runtime as part of your build step to reduce the deployment size.
 
 ### Environment flags
 
diff --git a/packages/profiling-node/package.json b/packages/profiling-node/package.json
index f42315675c1a..ae8b355ed7a2 100644
--- a/packages/profiling-node/package.json
+++ b/packages/profiling-node/package.json
@@ -22,9 +22,6 @@
       }
     }
   },
-  "bin": {
-    "sentry-prune-profiler-binaries": "scripts/prune-profiler-binaries.js"
-  },
   "engines": {
     "node": ">=20.19.0 <22.0.0 || >=22.12.0 <23.0.0 || >=23.2.0"
   },
@@ -33,8 +30,7 @@
   },
   "files": [
     "/build",
-    "package.json",
-    "/scripts/prune-profiler-binaries.js"
+    "package.json"
   ],
   "scripts": {
     "clean": "rm -rf build",
diff --git a/packages/profiling-node/scripts/prune-profiler-binaries.js b/packages/profiling-node/scripts/prune-profiler-binaries.js
deleted file mode 100755
index fc45fbcbe35a..000000000000
--- a/packages/profiling-node/scripts/prune-profiler-binaries.js
+++ /dev/null
@@ -1,204 +0,0 @@
-#! /usr/bin/env node
-
-// This is a build script, so some logging is desirable as it allows
-// us to follow the code path that triggered the error.
-/* eslint-disable no-console */
-const fs = require('fs');
-
-let SOURCE_DIR, PLATFORM, ARCH, STDLIB, NODE, HELP;
-
-for (let i = 0; i < process.argv.length; i++) {
-  const arg = process.argv[i];
-  if (arg.startsWith('--target_dir_path=')) {
-    SOURCE_DIR = arg.split('=')[1];
-    continue;
-  }
-
-  if (arg.startsWith('--target_platform=')) {
-    PLATFORM = arg.split('=')[1];
-    continue;
-  }
-
-  if (arg.startsWith('--target_arch=')) {
-    ARCH = arg.split('=')[1];
-    continue;
-  }
-
-  if (arg.startsWith('--target_stdlib=')) {
-    STDLIB = arg.split('=')[1];
-    continue;
-  }
-
-  if (arg.startsWith('--target_node=')) {
-    NODE = arg.split('=')[1];
-    continue;
-  }
-
-  if (arg === '--help' || arg === '-h') {
-    HELP = true;
-    continue;
-  }
-}
-
-if (HELP) {
-  console.log(
-    `\nSentry: Prune profiler binaries\n
-Usage: sentry-prune-profiler-binaries --target_dir_path=... --target_platform=... --target_arch=... --target_stdlib=...\n
-Arguments:\n
---target_dir_path: Path to the directory containing the final bundled code. If you are using webpack, this would be the equivalent of output.path option.\n
---target_node: The major node version the code will be running on. Example: 16, 18, 20...\n
---target_platform: The platform the code will be running on. Example: linux, darwin, win32\n
---target_arch: The architecture the code will be running on. Example: x64, arm64\n
---target_stdlib: The standard library the code will be running on. Example: glibc, musl\n
---dry-run: Do not delete any files, just print the files that would be deleted.\n
---help: Print this help message.\n`,
-  );
-  process.exit(0);
-}
-
-console.warn(
-  '[Sentry] Warning: This script will be removed in the next major version. See: https://github.com/getsentry/sentry-javascript/issues/20567',
-);
-
-const ARGV_ERRORS = [];
-
-const NODE_TO_ABI = {
-  16: '93',
-  18: '108',
-  20: '115',
-  22: '127',
-  24: '137',
-  26: '147',
-};
-
-if (NODE) {
-  if (NODE_TO_ABI[NODE]) {
-    NODE = NODE_TO_ABI[NODE];
-  } else if (NODE.startsWith('16')) {
-    NODE = NODE_TO_ABI['16'];
-  } else if (NODE.startsWith('18')) {
-    NODE = NODE_TO_ABI['18'];
-  } else if (NODE.startsWith('20')) {
-    NODE = NODE_TO_ABI['20'];
-  } else if (NODE.startsWith('22')) {
-    NODE = NODE_TO_ABI['22'];
-  } else if (NODE.startsWith('24')) {
-    NODE = NODE_TO_ABI['24'];
-  } else if (NODE.startsWith('26')) {
-    NODE = NODE_TO_ABI['26'];
-  } else {
-    ARGV_ERRORS.push(
-      `❌ Sentry: Invalid node version passed as argument, please make sure --target_node is a valid major node version. Supported versions are ${Object.keys(
-        NODE_TO_ABI,
-      ).join(', ')}.`,
-    );
-  }
-}
-
-if (!SOURCE_DIR) {
-  ARGV_ERRORS.push(
-    '❌ Sentry: Missing target_dir_path argument. target_dir_path should point to the directory containing the final bundled code. If you are using webpack, this would be the equivalent of output.path option.',
-  );
-}
-
-if (!PLATFORM && !ARCH && !STDLIB) {
-  ARGV_ERRORS.push(
-    `❌ Sentry: Missing argument values, pruning requires either --target_platform, --target_arch or --target_stdlib to be passed as argument values.\n Example: sentry-prune-profiler-binaries --target_platform=linux --target_arch=x64 --target_stdlib=glibc\n
-If you are unsure about the execution environment, you can opt to skip some values, but at least one value must be passed.`,
-  );
-}
-
-if (ARGV_ERRORS.length > 0) {
-  console.log(ARGV_ERRORS.join('\n'));
-  process.exit(1);
-}
-
-const SENTRY__PROFILER_BIN_REGEXP = /sentry_cpu_profiler-.*\.node$/;
-
-async function findSentryProfilerBinaries(source_dir) {
-  const binaries = new Set();
-  const queue = [source_dir];
-
-  while (queue.length > 0) {
-    const dir = queue.pop();
-
-    for (const file of fs.readdirSync(dir)) {
-      if (SENTRY__PROFILER_BIN_REGEXP.test(file)) {
-        binaries.add(`${dir}/${file}`);
-        continue;
-      }
-
-      if (fs.statSync(`${dir}/${file}`).isDirectory()) {
-        if (file === 'node_modules') {
-          continue;
-        }
-
-        queue.push(`${dir}/${file}`);
-      }
-    }
-  }
-
-  return binaries;
-}
-
-function bytesToHumanReadable(bytes) {
-  if (bytes < 1024) {
-    return `${bytes} Bytes`;
-  } else if (bytes < 1048576) {
-    return `${(bytes / 1024).toFixed(2)} KiB`;
-  } else {
-    return `${(bytes / 1048576).toFixed(2)} MiB`;
-  }
-}
-
-async function prune(binaries) {
-  let bytesSaved = 0;
-  let removedBinariesCount = 0;
-
-  const conditions = [PLATFORM, ARCH, STDLIB, NODE].filter(n => !!n);
-
-  for (const binary of binaries) {
-    if (conditions.every(condition => binary.includes(condition))) {
-      continue;
-    }
-
-    const stats = fs.statSync(binary);
-    bytesSaved += stats.size;
-    removedBinariesCount++;
-
-    if (process.argv.includes('--dry-run')) {
-      console.log(`Sentry: would have pruned ${binary} (${bytesToHumanReadable(stats.size)})`);
-      continue;
-    }
-
-    console.log(`Sentry: pruned ${binary} (${bytesToHumanReadable(stats.size)})`);
-    fs.unlinkSync(binary);
-  }
-
-  if (removedBinariesCount === 0) {
-    console.log(
-      '❌ Sentry: no binaries pruned, please make sure target argument values are valid or use --help for more information.',
-    );
-    return;
-  }
-
-  if (process.argv.includes('--dry-run')) {
-    console.log(
-      `✅ Sentry: would have pruned ${removedBinariesCount} ${
-        removedBinariesCount === 1 ? 'binary' : 'binaries'
-      } and saved ${bytesToHumanReadable(bytesSaved)}.`,
-    );
-    return;
-  }
-
-  console.log(
-    `✅ Sentry: pruned ${removedBinariesCount} ${
-      removedBinariesCount === 1 ? 'binary' : 'binaries'
-    }, saved ${bytesToHumanReadable(bytesSaved)} in total.`,
-  );
-}
-
-(async () => {
-  const binaries = await findSentryProfilerBinaries(SOURCE_DIR);
-  await prune(binaries);
-})();
diff --git a/packages/profiling-node/test/prune-profiler-binaries.test.ts b/packages/profiling-node/test/prune-profiler-binaries.test.ts
deleted file mode 100644
index 174eab6a9879..000000000000
--- a/packages/profiling-node/test/prune-profiler-binaries.test.ts
+++ /dev/null
@@ -1,24 +0,0 @@
-import { spawnSync } from 'node:child_process';
-import * as os from 'node:os';
-import * as path from 'node:path';
-import { describe, expect, it } from 'vitest';
-
-describe('prune-profiler-binaries', () => {
-  it('should check if the node version is valid', () => {
-    const currentNode = process.version.split('v')[1];
-    const result = spawnSync(
-      'node',
-      [
-        path.join(__dirname, '../scripts/prune-profiler-binaries.js'),
-        '--target_platform=linux',
-        '--target_arch=x64',
-        '--target_stdlib=glibc',
-        `--target_dir_path=${os.tmpdir()}`,
-        `--target_node=${currentNode}`,
-      ],
-      { encoding: 'utf8' },
-    );
-
-    expect(result.stdout).not.toContain('Invalid node version passed as argument');
-  });
-});