diff --git a/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs b/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs
index 7dc65dc4f5ad8c..14f0f9b6c1e33a 100644
--- a/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs
+++ b/src/coreclr/tools/aot/ILCompiler.RyuJit/JitInterface/CorInfoImpl.RyuJit.cs
@@ -1450,15 +1450,26 @@ private void getCallInfo(ref CORINFO_RESOLVED_TOKEN pResolvedToken, CORINFO_RESO
 
                 if (pResult->exactContextNeedsRuntimeLookup)
                 {
-                    MethodDesc caller = HandleToObject(callerHandle);
-
                     pResult->codePointerOrStubLookup.lookupKind.needsRuntimeLookup = true;
-                    pResult->codePointerOrStubLookup.runtimeLookup.indirections = CORINFO.USEHELPER;
-                    pResult->codePointerOrStubLookup.runtimeLookup.helper = CorInfoHelpFunc.CORINFO_HELP_READYTORUN_GENERIC_HANDLE;
-                    pResult->codePointerOrStubLookup.lookupKind.runtimeLookupKind = GetGenericRuntimeLookupKind(caller);
-                    object helperArg = GetRuntimeDeterminedObjectForToken(ref pResolvedToken);
-                    ISymbolNode helper = GetGenericLookupHelper(pResult->codePointerOrStubLookup.lookupKind.runtimeLookupKind, ReadyToRunHelperId.MethodEntry, caller, helperArg);
-                    pResult->codePointerOrStubLookup.runtimeLookup.helperEntryPoint = CreateConstLookupToSymbol(helper);
+
+                    // If this is from a different context, abort. The ReadyToRun helper needs to declare
+                    // its dependencies in terms of the dictionary it will be placed in, but the runtime
+                    // determined method we computed is expressed in terms of the inlinee's generic context.
+                    if (pResolvedToken.tokenContext != contextFromMethodBeingCompiled())
+                    {
+                        pResult->codePointerOrStubLookup.lookupKind.runtimeLookupKind = CORINFO_RUNTIME_LOOKUP_KIND.CORINFO_LOOKUP_NOT_SUPPORTED;
+                    }
+                    else
+                    {
+                        MethodDesc caller = HandleToObject(callerHandle);
+
+                        pResult->codePointerOrStubLookup.runtimeLookup.indirections = CORINFO.USEHELPER;
+                        pResult->codePointerOrStubLookup.runtimeLookup.helper = CorInfoHelpFunc.CORINFO_HELP_READYTORUN_GENERIC_HANDLE;
+                        pResult->codePointerOrStubLookup.lookupKind.runtimeLookupKind = GetGenericRuntimeLookupKind(caller);
+                        object helperArg = GetRuntimeDeterminedObjectForToken(ref pResolvedToken);
+                        ISymbolNode helper = GetGenericLookupHelper(pResult->codePointerOrStubLookup.lookupKind.runtimeLookupKind, ReadyToRunHelperId.MethodEntry, caller, helperArg);
+                        pResult->codePointerOrStubLookup.runtimeLookup.helperEntryPoint = CreateConstLookupToSymbol(helper);
+                    }
                 }
                 else
                 {
diff --git a/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs b/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs
index 8eca170739f971..6febd238358128 100644
--- a/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs
+++ b/src/tests/nativeaot/SmokeTests/UnitTests/Generics.cs
@@ -64,6 +64,7 @@ internal static int Run()
         TestGenericInliningTypeGenericsOnly.Run();
         Test99198Regression.Run();
         Test102259Regression.Run();
+        Test129093Regression.Run();
         Test104913Regression.Run();
         Test105397Regression.Run();
         Test105880Regression.Run();
@@ -3790,6 +3791,33 @@ public static void Run()
         }
     }
 
+    class Test129093Regression
+    {
+        class Gen<T>
+        {
+            [MethodImpl(MethodImplOptions.NoInlining)]
+            public static Type Method() => typeof(T);
+        }
+
+        // Inlineable generic method taking the address of a method that needs a generic context.
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        static unsafe nint GetPtr<U>() => (nint)(delegate*<Type>)&Gen<U>.Method;
+
+        class Caller<X>
+        {
+            [MethodImpl(MethodImplOptions.NoInlining)]
+            public static nint Run() => GetPtr<X>();
+        }
+
+        public static unsafe void Run()
+        {
+            if (((delegate*<Type>)Caller<object>.Run())() != typeof(object))
+                throw new Exception();
+            if (((delegate*<Type>)Caller<string>.Run())() != typeof(string))
+                throw new Exception();
+        }
+    }
+
     class Test104913Regression
     {
         interface IFoo