diff --git a/CHANGELOG.md b/CHANGELOG.md
index 9d729c7..4c014f0 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 Babashka [http-client](https://github.com/babashka/http-client): HTTP client for Clojure and babashka built on java.net.http
 
+## Unreleased
+
+- [#80](https://github.com/babashka/http-client/issues/80): accept a function of the request URI in `:proxy` to select a proxy per request ([@jeeger](https://github.com/jeeger))
+
 ## 0.4.23 (2025-06-06)
 
 - [#75](https://github.com/babashka/http-client/issues/75): override existing content type header in multipart request
diff --git a/src/babashka/http_client.clj b/src/babashka/http_client.clj
index 36dbb84..27c0a94 100644
--- a/src/babashka/http_client.clj
+++ b/src/babashka/http_client.clj
@@ -7,12 +7,19 @@
   i/default-client-opts)
 
 (defn ->ProxySelector
-  "Constructs a `java.net.ProxySelector`.
+  "Constructs a `java.net.ProxySelector` from a map of options, or from a
+  function of a `java.net.URI` returning such a map to select a proxy per
+  request. The function may return `nil` to connect directly.
+
   Options:
   * `:host` - string
-  * `:port` - long"
-  [opts]
-  (i/->ProxySelector opts))
+  * `:port` - long
+  * `:type` - `:http` (default) or `:direct`, which ignores `:host` and `:port`.
+    `java.net.http` connects through HTTP proxies only."
+  [opts-or-fn]
+  (if (instance? java.net.ProxySelector opts-or-fn)
+    opts-or-fn
+    (i/->ProxySelector opts-or-fn)))
 
 (defn ->SSLContext
   "Constructs a `javax.net.ssl.SSLContext`.
diff --git a/src/babashka/http_client/internal.clj b/src/babashka/http_client/internal.clj
index dea6807..b7aa123 100644
--- a/src/babashka/http_client/internal.clj
+++ b/src/babashka/http_client/internal.clj
@@ -97,13 +97,43 @@
                trust-managers
                (SecureRandom.))))))
 
-(defn ->ProxySelector
+(defn- ->Proxy
   [opts]
-  (if (instance? java.net.ProxySelector opts)
+  (if (instance? java.net.Proxy opts)
     opts
-    (let [{:keys [host port]} opts]
-      (cond (and host port)
-            (java.net.ProxySelector/of (java.net.InetSocketAddress. ^String host ^long port))))))
+    (let [{:keys [host port type] :or {type :http}} opts]
+      (case type
+        :direct java.net.Proxy/NO_PROXY
+        :http (if (and host port)
+                (java.net.Proxy. java.net.Proxy$Type/HTTP
+                                 (java.net.InetSocketAddress. ^String host ^long port))
+                (throw (ex-info "Proxy needs both :host and :port." {:opts opts})))
+        (throw (ex-info (str "Unsupported proxy type: " (pr-str type)
+                             ". java.net.http connects through HTTP proxies only.")
+                        {:opts opts}))))))
+
+(defn ->ProxySelector
+  [opts-or-fn]
+  (cond
+    (instance? java.net.ProxySelector opts-or-fn)
+    opts-or-fn
+    (fn? opts-or-fn)
+    ;; Create a dynamic proxy selector.
+    (proxy [java.net.ProxySelector] []
+      (connectFailed [_ _ _])
+      (select [^URI uri]
+        ;; Only allow the proxy function to return a single proxy.
+        ;; Returning multiple is currently not supported.
+        [(if-let [proxy-values (opts-or-fn uri)]
+           (->Proxy proxy-values)
+           java.net.Proxy/NO_PROXY)]))
+    :else
+    ;; Return a static proxy configuration that always returns the same proxy.
+    (let [static-proxy (->Proxy opts-or-fn)]
+      (proxy [java.net.ProxySelector] []
+        (connectFailed [_ _ _])
+        (select [^URI _uri]
+          [static-proxy])))))
 
 (defn ->Authenticator
   [v]
diff --git a/test/babashka/http_client/internal/helpers_test.clj b/test/babashka/http_client/internal/helpers_test.clj
index ef03e82..6562c5b 100644
--- a/test/babashka/http_client/internal/helpers_test.clj
+++ b/test/babashka/http_client/internal/helpers_test.clj
@@ -4,5 +4,5 @@
    [clojure.test :as t]))
 
 (t/deftest ->uri-tests
-  (let [uri (h/->uri {:scheme "https" :host "example.com" :path "/foo"})]
+  (let [^java.net.URI uri (h/->uri {:scheme "https" :host "example.com" :path "/foo"})]
     (t/is (= (.getPort uri) -1))))
diff --git a/test/babashka/http_client_test.clj b/test/babashka/http_client_test.clj
index bb58a96..bee92a9 100644
--- a/test/babashka/http_client_test.clj
+++ b/test/babashka/http_client_test.clj
@@ -510,8 +510,44 @@
 
 (deftest proxy-selector
   (is (instance? java.net.ProxySelector
-                 (http/->ProxySelector {:host "https://clojure.org"
-                                        :port 1337}))))
+                 (http/->ProxySelector {:host "clojure.org"
+                                        :port 1337})))
+  (testing "a ProxySelector is passed through"
+    (is (instance? java.net.ProxySelector
+                   (http/->ProxySelector
+                    (http/->ProxySelector {:host "clojure.org"
+                                           :port 1337})))))
+  (testing "a function selects a proxy per request"
+    (let [^java.net.ProxySelector selector
+          (http/->ProxySelector (fn [^java.net.URI uri]
+                                  (when (= (.getScheme uri) "http")
+                                    {:host "www.example.org"
+                                     :port 128})))
+          proxies-for-http (.select selector (java.net.URI. "http://www.example.org"))
+          proxies-for-https (.select selector (java.net.URI. "https://www.example.org"))]
+      (is (= (count proxies-for-http) (count proxies-for-https) 1))
+      (is (= (.type ^java.net.Proxy (get proxies-for-http 0)) java.net.Proxy$Type/HTTP))
+      (is (= (.address ^java.net.Proxy (get proxies-for-http 0))
+             (java.net.InetSocketAddress. "www.example.org" 128)))
+      (testing "returning nil connects directly"
+        (is (= (.type ^java.net.Proxy (get proxies-for-https 0)) java.net.Proxy$Type/DIRECT)))))
+  (testing "a map always selects the same proxy"
+    (let [^java.net.ProxySelector selector (http/->ProxySelector {:host "127.0.0.1"
+                                                                  :port 8081})
+          selected (.select selector (java.net.URI. "http://www.example.org"))]
+      (is (= (count selected) 1))
+      (is (= (.type ^java.net.Proxy (selected 0)) java.net.Proxy$Type/HTTP))
+      (is (= (.address ^java.net.Proxy (selected 0)) (java.net.InetSocketAddress. "127.0.0.1" 8081)))))
+  (testing ":direct ignores host and port"
+    (let [^java.net.ProxySelector selector (http/->ProxySelector {:type :direct})]
+      (is (= (.type ^java.net.Proxy ((.select selector (java.net.URI. "http://www.example.org")) 0))
+             java.net.Proxy$Type/DIRECT))))
+  (testing "java.net.http supports HTTP proxies only"
+    (is (thrown-with-msg? clojure.lang.ExceptionInfo #"Unsupported proxy type"
+                          (http/->ProxySelector {:host "127.0.0.1" :port 8081 :type :socks}))))
+  (testing "a proxy needs host and port"
+    (is (thrown-with-msg? clojure.lang.ExceptionInfo #":host and :port"
+                          (http/->ProxySelector {:host "127.0.0.1"})))))
 
 (deftest cookie-handler-test
   (testing "nil passthrough"