diff --git a/bionetgen/__main__.py b/bionetgen/__main__.py
new file mode 100644
index 00000000..0da9232d
--- /dev/null
+++ b/bionetgen/__main__.py
@@ -0,0 +1,6 @@
+"""Module entry point for ``python -m bionetgen``."""
+
+from .main import main
+
+if __name__ == "__main__":
+    main()
diff --git a/tests/test_module_entrypoint.py b/tests/test_module_entrypoint.py
new file mode 100644
index 00000000..bb3332df
--- /dev/null
+++ b/tests/test_module_entrypoint.py
@@ -0,0 +1,29 @@
+import subprocess
+import sys
+from pathlib import Path
+
+REPO_ROOT = Path(__file__).resolve().parents[1]
+
+
+def _run_module(*args):
+    return subprocess.run(
+        [sys.executable, "-m", "bionetgen", *args],
+        cwd=REPO_ROOT,
+        capture_output=True,
+        text=True,
+        check=False,
+    )
+
+
+def test_python_m_bionetgen_help():
+    result = _run_module("--help")
+
+    assert result.returncode == 0
+    assert "usage:" in (result.stdout + result.stderr).lower()
+
+
+def test_python_m_bionetgen_require_help():
+    result = _run_module("-req", "0.5.0", "--help")
+
+    assert result.returncode == 0
+    assert "usage:" in (result.stdout + result.stderr).lower()