diff --git a/packages/controller-utils/CHANGELOG.md b/packages/controller-utils/CHANGELOG.md
index 487e484d820..19d247d5f78 100644
--- a/packages/controller-utils/CHANGELOG.md
+++ b/packages/controller-utils/CHANGELOG.md
@@ -11,6 +11,11 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 - Add optional `startTime` to `TraceRequest` to allow backdating a span's start time ([#9315](https://github.com/MetaMask/core/pull/9315))
 
+### Changed
+
+- Widen `isSafeDynamicKey` parameter type from `string` to `PropertyKey` ([#9774](https://github.com/MetaMask/core/pull/9774))
+  - `number` and `symbol` keys are now considered safe and return `true`; previously any non-string input returned `false`
+
 ### Deprecated
 
 - Deprecate `createServicePolicy` and related symbols ([#9418](https://github.com/MetaMask/core/pull/9418))
diff --git a/packages/controller-utils/src/util.test.ts b/packages/controller-utils/src/util.test.ts
index e3346ea473f..19f9e61d47b 100644
--- a/packages/controller-utils/src/util.test.ts
+++ b/packages/controller-utils/src/util.test.ts
@@ -33,8 +33,15 @@ describe('util', () => {
     for (const badKey of util.PROTOTYPE_POLLUTION_BLOCKLIST) {
       expect(util.isSafeDynamicKey(badKey)).toBe(false);
     }
-    // @ts-expect-error - ensure that non-string input return false.
+    expect(util.isSafeDynamicKey(0)).toBe(true);
+    expect(util.isSafeDynamicKey(123)).toBe(true);
+    expect(util.isSafeDynamicKey(Number.NaN)).toBe(true);
+    expect(util.isSafeDynamicKey(Symbol('__proto__'))).toBe(true);
+    expect(util.isSafeDynamicKey(Symbol.iterator)).toBe(true);
+    // @ts-expect-error - ensure that non-`PropertyKey` input returns false.
     expect(util.isSafeDynamicKey(null)).toBe(false);
+    // @ts-expect-error - ensure that non-`PropertyKey` input returns false.
+    expect(util.isSafeDynamicKey(undefined)).toBe(false);
   });
   it('isSafeChainId', () => {
     expect(util.isSafeChainId(util.toHex(MAX_SAFE_CHAIN_ID + 1))).toBe(false);
diff --git a/packages/controller-utils/src/util.ts b/packages/controller-utils/src/util.ts
index 71a0f8c5430..8d1790bdd14 100644
--- a/packages/controller-utils/src/util.ts
+++ b/packages/controller-utils/src/util.ts
@@ -31,14 +31,21 @@ export const PROTOTYPE_POLLUTION_BLOCKLIST = [
  * Checks whether a dynamic property key could be used in
  * a [prototype pollution attack](https://portswigger.net/web-security/prototype-pollution).
  *
+ * String keys are compared against the {@link PROTOTYPE_POLLUTION_BLOCKLIST}.
+ * Number and symbol keys are always considered safe: number keys are coerced
+ * to numeric strings, which can never collide with the blocklist, and symbol
+ * keys cannot alias the string-keyed `Object.prototype` properties.
+ *
  * @param key - The dynamic key to validate.
  * @returns Whether the given dynamic key is safe to use.
  */
-export function isSafeDynamicKey(key: string): boolean {
-  return (
-    typeof key === 'string' &&
-    !PROTOTYPE_POLLUTION_BLOCKLIST.some((blockedKey) => key === blockedKey)
-  );
+export function isSafeDynamicKey(key: PropertyKey): boolean {
+  if (typeof key === 'string') {
+    return !PROTOTYPE_POLLUTION_BLOCKLIST.some(
+      (blockedKey) => key === blockedKey,
+    );
+  }
+  return typeof key === 'number' || typeof key === 'symbol';
 }
 
 /**